The museum, recently re-opened after years of renovation, is housed in the eighteenth-century villa that belonged to the Sartorio family.
It preserves nineteenth-century original furniture, a collection of precious ceramics, rich art collections, the Rusconi-Opuich collection that comprises about 2500 pieces of various kinds from ancient art to the 20th century (paintings, drawings, prints, jewels, textiles, silverware, etc.), the important collection of Tiepolo drawings, the Triptych of Santa Chiara, a masterpiece of fourteenth-century art in Trieste.
The basements feature the collections of applied art, jewels and the remains of a Roman domus of the first century A.D. brought to light during the renovation.
The picture gallery, located in the rooms of the old stable, comprises over a thousand paintings of the collections of the Municipal Museums of History and Art.
The former carriage depot was transformed into a Collection of plaster casts-Glyptothek, with about six hundred sculptures of the 19th-20th centuries.